Basic fibroblast growth factor (bFGF) and its application in accelerating acute wound healing.In general, acute wound healing process is convenient to divide the overall into three overlapping phases: inflammatory phase, proliferative phase and maturation phase.Growth factors regulate and coordinate these processes, bFGF is a member of a family of heparin-binding growth factors that has been implicated as an important mediator in wound healing.We (Fu and Li et al) carried out a randomized placebo-controlled trial of use of recombinant bovine basic fibroblast growth factor (rbFGF) for second-degree bums in 600 patients.This was the first report about its use in acute wound healing.Our results showed that all patients treated with rbFGF had faster granulation tissue formation and epidermal regeneration than those in the placebo control group.Superficial and deep second-degree burns treated with rbFGF healed in a mean of 9.9 (SD 2.5) days and 17.0 (4.6) days, respectively, compared with 12.4 (SD 2.7) and 21.2 (4.9) days.No adverse effects were seen locally or systemically.