【摘 要】
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Backgrounds Genetic polymorphism of matrix metalloproteinase (MMP) family has been hypothesized to play a critical role in head/neck cancer development.However, the results of recent studies on this r
【机 构】
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Affiliated Stomatological Hospital of Nanjing Medical University Nanjing,Jiangsu 210029,China
【出 处】
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11th Asian Congress on Oeal and Maxillofacial Surgery(第十一届亚洲
论文部分内容阅读
Backgrounds Genetic polymorphism of matrix metalloproteinase (MMP) family has been hypothesized to play a critical role in head/neck cancer development.However, the results of recent studies on this relationship remain inconsistent.To elucidate the association, we performed this meta-analysis.Methods All studies evaluating the association between polymorphisms of MMP 1-1607 1G/2G, MMP2-1306 C/T, MMP3-1171 5A/6A and MMP9-1562 C/T and head/neck cancer risk were identified by a search in PubMed, ISI Web of Knowledge, MEDLINE, Embase, Google Scholar and CNKI database.Odds ratios (ORs) with 95％ confidence interval (CIs) were used to evaluate the strength of the association.Subgroup analyses by different ethnicity were performed to further identify the association.Statistical analysis was performed with Review Manager 5.2.
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