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  5. ASIC1a regulates insular long-term depression and is required for extinction of conditioned taste av

ASIC1a regulates insular long-term depression and is required for extinction of conditioned taste av

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：daiguisheng613
【摘 要】
：
The synaptic function of acid-sensing ion channel 1a(ASIC1a)is emerging to be understood.Here,we identify a crucial role of ASIC1a in synaptic plasticity at mouse insular synapses.Whereas genetic abla
【作 者】
：
Wei-Guang Li Tian-Le Xu 
【机 构】
：
Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China
【出 处】
：
2016年国际生理学学术大会
【发表日期】
：
2016年6期
【关键词】
：
ASIC1a long-term depression extinction learning behavioral flexibility insular c 
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　　The synaptic function of acid-sensing ion channel 1a(ASIC1a)is emerging to be understood.Here,we identify a crucial role of ASIC1a in synaptic plasticity at mouse insular synapses.Whereas genetic ablation and pharmacological inhibition of ASIC1a reduced the induction probability of long-term depression(LTD),they did not affect long-term potentiation in insular cortex.
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