【摘 要】
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Early growth response (Egr)-1 is an upstream master switch in controlling inflammatory responses following myocardial ischemia-reperfusion (I/R).1 Activation of extracellular signal-regulated protein
【机 构】
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Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine,Shang
【出 处】
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中华医学会第22次全国麻醉学术年会
论文部分内容阅读
Early growth response (Egr)-1 is an upstream master switch in controlling inflammatory responses following myocardial ischemia-reperfusion (I/R).1 Activation of extracellular signal-regulated protein kinase-1 and 2 (ERK1/2) signaling is known to up-regulate Egr-1.2 Considering the previous findings that ERK1/2 pathway is necessary for the therapeutic action of electro-acupucture (EA)3, we speculated that EA at Neiguan (PC6) could inhibit Egr-1 expression via the ERK1/2 pathway, and subsequently reduce inflammatory responses and myocardial I/R injury.
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