Identification of SENP1 inhibitors with novel scaffolds through in silico screening and rational dru

来源 :第十三届全国计算机化学学会会议 | 被引量 : 0次 | 上传用户：fdghghjhghjjh

【摘要】

：

　　The small ubiquitin-related modifier(SUMO)-specific proteases(SENPs)catalyze the maturation of SUMO precursors(pre-SUMOs)and deconjugation of SUMO from thei

【作者】

：

Yaxue Zhao Zhongli Wang Jianchen Zhang Huchen Zhou

【机构】

：

SchoolofPharmacy,ShanghaiJiaoTongUniversity,Shanghai200240,China

【出处】

：

第十三届全国计算机化学学会会议

【发表日期】

：

2015年11期

【关键词】

：

SENP1 inhibitor in silico screening rational design cancer

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　　The small ubiquitin-related modifier(SUMO)-specific proteases(SENPs)catalyze the maturation of SUMO precursors(pre-SUMOs)and deconjugation of SUMO from their modified proteins.SENP1 which is the most studied isoform is closely related to many cancers such as prostate cancer and colon cancer.

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Identification of SENP1 inhibitors with novel scaffolds through in silico screening and rational dru

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