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N-methylpyrrolidine is used as raw material for synthesis of cefepime hydrochloride.A N-methylpyrrolidine group which may be decomposed from cephalosporin-ene skeleton lies in three side chain of cefepime nucleus,resulting in residue [1-3].As N-methylpyrrolidine is toxic to human and environment,it is very important to detect the content of N-methylpyrrolidine in the process of controlling the qualities of products.N-methylpyrrolidine in cefepime hydrochloride for injection was detected by capillary electrophoresis with indirect UV detection in this paper.