Background:Porcine circovirus type 2 (PCV2) is associated with post-weaning multisystemic wasting syndrome (PMWS) in pigs.The C-terminus of PCV2 capsid protein tolerates insertions of exogenous epitope,and elicits both anti-epitope tag antibodies and anti-PCV2 neutralizing antibodies.The recombinant PCV2 expressing the neutralizing VP1 epitope (aa 141-160) of foot-and-mouth disease virus (FMDV) type O was generated,and its immunogenicity was evaluate in the mice model.