Prognostic Value of Chronic Hepatitis B Virus Infection in Patients with Nasopharyngeal Carcinoma: A

来源 :第九届泛珠江区域放射肿瘤学学术大会暨肿瘤放射治疗多中心协作研讨会、重庆市医学会放射肿瘤治疗学专业委员会2014年会 | 被引量 : 0次 | 上传用户:tangweichao
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Background: Both nasopharyngeal carcinoma (NPC) and hepatitis B virus (HBV) infection are prevalent in southern China.Recently, HBV-infected patients with diffuse large B-cell lymphoma or multiple myeloma were found to have distinct clinical characteristics and/or outcomes compared to uninfected patients.However, the clinical features of patients with NPC and chronic HBV infection have not been elucidated.Thus, we investigated the prevalence and prognostic value of chronic HBV infection in patients with NPC in southern China.Methods: A total of 1301 patients with non-metastatic NPC treated at the Sun Yat-sen University Cancer Center between 2003 and 2007 were retrospectively reviewed.Chronic HBV infection was defined as hepatitis B surface antigen (HBsAg)-seropositivity.All patients were restaged according to the 7th edition of AJCC NPC staging system.Results: In this series, 10.9% (142/1301) of patients had chronic HBV infection.The proportion of non-cancer related deaths (15.0% vs.12.1%, P=0.618)and severe hepatic adverse events (3.5% vs.0.9%;P=0.145) were similar in HBV-infected and uninfected patients with NPC.The 5-year overall survival (OS), progression-free survival (PFS), and locoregional relapse-free survival (LRFS) rates for HBV-infected and uninfected patients with NPC were 70.9% and 80.8% (P=0.003),63.7% and 73.0% (P=0.016), and 81.7% and 88.2% (P=0.035), respectively.Multivariate analysis identified chronic HBV infection as an independent unfavorable prognostic factor inNPC for OS (HR 1.684, 95% CI 1.198-2.366;P =0.003), PFS (HR 1.451, 95% CI 1.076-1.955;P =0.015) and LRFS (HR 1.573, 95% CI 1.005-2.463;P =0.048).Conclusion: This study demonstrates that chronic HBV infection is an independent prognostic factor associated with unfavorable prognosis in patients with NPC.Further studies are needed to better understand the underlying mechanisms.
其他文献
  目的:对比分析宫颈癌高剂量率近距离治疗逆向计划(IPSA)与常规A点归一计划(AP)和图解优化计划(GrO)的剂量学差异.方法: 选取置入三管(宫腔管和阴道双侧穹窿管)进行高剂量率
  1、分布式光伏标准化产品开发2、分布式市场推广
  1.海外光伏电站具有收益高,政策稳定,风险低的特点.由于日本等国家光伏补贴政策的确定,日本成为今年最火爆的光伏市场.本演讲将以日本市场为重点,分析日本市场和墨西哥、德国
英语是一门非常广泛的语言,英语的学习可以是简单也可以是复杂,学生在学习英语时,需要具有良好的记忆力来进行记忆生词,所以,教师在对学生进行教学的时候,就需要利用思维导图
  本文研究发现管式PECVD技术中的预处理工艺对晶体硅电池片的电性能有重要影响。通过对比保留与去除预处理工艺太阳电池性能的表现,发现采用当前主流硅片材料的情况下,去除
  介绍先进的太阳能资源评估方法及在实际项目融资时的作用及服务应用
  目的:探讨螺旋断层放疗治疗胸部肿瘤时MVCT图像引导下分次间的摆位误差.方法:选择我科20例胸部肿瘤患者,其中肺癌患者16例,食管癌患者4例,男性15例,女性5例,年龄38-65岁,平
会议
  本文研究发现管式PECVD技术中的预处理工艺对晶体硅电池片的电性能有重要影响。通过对比保留与去除预处理工艺太阳电池性能的表现,发现采用当前主流硅片材料的情况下,去除
阿诺什·艾拉尼是加拿大极具影响力的当代新锐作家,其作品《没有悲伤的城市》深度聚焦印度孟买战乱现状.本文笔者在分析文本“反战”主题内涵和特点的基础上,将围绕小说的“
  This presentation will provide an overview of the relationship and future direction of crystalline silicon growing technology; including directional solidif
会议