Lack of regioselectivity in Fischer indole synthesis largely prevents its application in the synthesis of complex indole alkaloids.We have developed new chemistry to solve the regioselectivity issue based on the strategy of forming the enehydrazine intermediates directly through coupling of phenylhydrazines with vinyl halides.This new entry into the classic reaction allows us to not only fulfill selective synthesis of isomeric indoles but also to develop interrupted indolizations to conveniently synthesize complex pyrrolidinoindoline framework.