【摘 要】
：
Congenital human cytomegalovirus (HCMV) infection is the most frequent infectious cause of birth defects, primarily neurological disorders.Neural progenitor/stem cells (NPCs) are the major cell type i
【机 构】
：
State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, 44 Wucha
论文部分内容阅读
Congenital human cytomegalovirus (HCMV) infection is the most frequent infectious cause of birth defects, primarily neurological disorders.Neural progenitor/stem cells (NPCs) are the major cell type in the subventricular zone and are susceptible to HCMV infection.In culture, the differentiation status of NPCs may change with passage, which in turn may alter susceptibility to virus infection.
其他文献
To analyze the colonization of the lesional sites of pityriasis versicolor (PV) in Chinese patients with Malassezia globosa, Malassezia restricta and Malassezia slooffiae by using a real-time PCR syst
Myxomycetes, a group of eukaryotic microorganisms, are widely spread in terrestrial ecosystem and have already reported approximately 1000 species so far.Based on morphological characteristics of frui
The 5-cap structure is a distinct feature of eukaryotic mRNAs, which is important for RNA stability and protein translation and provides a molecular signature for the distinction of self or non-self m
NF-κB plays central roles in regulating of diverse biological processes, including innate and adaptive immunity, inflammation.HSV-1 is the archetypal member of the alphaherpesvirus with a large genome
Viral infection initiates a series of signaling cascades that lead to the transcription of interferons (IFNs), fmally inducing interferon-stimulated genes (ISGs) to eliminate viruses.Viruses have evol
柯萨奇A16型病毒是手足口病的重要致病原之一,但自2008年安徽爆发EV71引起的手足口病以来,CA16病毒相关研究仍较少,阻碍了对新发肠道病毒致病机制的深入研究.CA16病毒通常引起的是轻症手足口病,但有时也可导致严重的神经系统症状.2009年广东手足口病爆发期间,我们从临床患者分离到2株CA16病毒,测序鉴定后命名为CA16/GD09/24 (KC117317)CA16/GD09/119(KC
疱疹性咽峡炎和手足口病在儿童中普遍流行.它们的临床特征均是皮肤和口腔黏膜损伤.从2007年，中国出现大规模手足口病的暴发，引起众多关注和相关病原的深入研究.然而，中国至今尚无对引起疱疹性咽峡炎的报道.2012年6月至8月，在中国东北吉林省长春市疱疹性咽峡炎流行季节期间，我们收集到42份确诊病患儿童的咽拭子标本.患儿年龄最小的11个月，最大的5岁零10个月，其中20名患儿为男孩.32份咽拭子标本经P
Background: Human cytomegalovirus (HCMV) encodes microRNAs (miRNAs) that function as posttranscriptional regulators of gene expression during lytic or latent infection.Some have been shown to suppress
The envelope protein plays the most important role in protective immunity to dengue viruses, and contains the main epitopes recognized by neutralizing antibodies.Recently, our group generated and char
Reassortment plays critical roles in influenza epidemic and pandemic.The molecular mechanism and the potential risk of reassortant pandemic HA are of importance and concern.In this study, the compatib