PIK3C2G缺失与结直肠癌患者FOLFOX化疗疗效的关系

来源 :2014第七届世界癌症大会 | 被引量 : 0次 | 上传用户：fengmiaoli

【摘要】

：

PIK3家族包括Ⅰ、Ⅱ、Ⅲ型.这个家族的基因在肿瘤中的生物学功能有很大差异.常见的PIK3CA在结直肠癌中呈现拷贝数扩增,是典型的癌基因；但是,这个家族另外的成员PIK3CG在结直肠癌发生中却呈现拷贝数缺失,被认为是一个抑癌基因.PIK3C2G,属于Ⅱ型PIK3基因.目前的研究表明它在慢性粒性白血病发病过程中被Bcr-Abl抑制,表达量显著降低,提示它在慢性粒性白血病发病过程中起抑制作用.

【作者】

：

李华光

【机构】

：

中国上海锐赛生物技术有限公司

【出处】

：

2014第七届世界癌症大会

【发表日期】

：

2014年12期

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PIK3C2G缺失与结直肠癌患者FOLFOX化疗疗效的关系

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