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脂肪细胞主要分为白色脂肪细胞和褐色脂肪细胞，它们在形态、基因表达以及功能等方面均存在差异，在特定情况下两者之间可以相互转换。解偶联蛋白UCP1特异性的表达在褐色脂肪细胞中，已有特异的UCP1-Cre遗传工具小鼠，用于褐色脂肪细胞示踪及基因敲除等功能研究。
建立白色脂肪细胞的特异遗传操作工具
【摘 要】
：
脂肪细胞主要分为白色脂肪细胞和褐色脂肪细胞，它们在形态、基因表达以及功能等方面均存在差异，在特定情况下两者之间可以相互转换。解偶联蛋白UCP1特异性的表达在褐色脂肪细胞中，已有特异的UCP1-Cre遗传工具小鼠，用于褐色脂肪细胞示踪及基因敲除等功能研究。
【机 构】
：
中国科学院上海生物化学与细胞生物学研究所
【出 处】
：
中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议
【发表日期】
：
2018年10期
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