Precise migration of neural stem/progenitor cells (NSCs) is crucially important for neurogenesis and repair in the nervous system.However,the detailed mechanisms are not clear.
It is widely known that ErbB2 (HER2/p185her2/neu) overexpression in human malignant cancers correlates with poor prognosis and the resistance against radiotherapy,chemotherapy and endocrine therapy.
Lineage transition in different subtypes of non-small cell lung cancer (NSCLC),as implicated by clinical observation of mixed adenocarcinoma (ADC) and squamous cell carcinoma (SCC) pathologies in aden
Neddylation is essential for the viability of most model organisms and involved in cancer development.In contrast with more than 600 ubiquitin ligases are known,less than ten Nedd8 ligases have been i
Tumorigenesis relies on the change of protein structure,modification and dosage.Modest protein dosage is indispensable for cellular growth and heredity.On the contrary some protein dosage rising drama
Human DNA polymerase iota (polι) possesses error-prone DNA replication features and performs translesion DNA synthesis.It may be specialized and highly regulated in normalmammalian cells;dysregulation
HOXC8 belongs to homeobox (HOX) family which comprises 39 members in mammalian species.It has been reported that HOXC8 expression is deregulated in several cancers and its expression is apparently upr
As a well-known phenomenon,total mRNAs poorly correlate to proteins in their abundances as reported.Recent findings calculated with bivariate models suggested even poorer such correlation,while focusi