【摘 要】
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M-type K+ channels, encoded by the KCNQ2-5 family of genes, play key roles in the regulation of neuronal excitability.We study the regulation of M-channel activity and transcriptional expression by A-
【机 构】
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University of Texas Health Sci Ctr.USA
【出 处】
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The 4th International Ion Channel Conference(第四届国际离子通道会议)
论文部分内容阅读
M-type K+ channels, encoded by the KCNQ2-5 family of genes, play key roles in the regulation of neuronal excitability.We study the regulation of M-channel activity and transcriptional expression by A-kinase-anchoring protein (AKAP) 79/150.Our FRET and functional studies suggest AKAP79/150 action correlates with the PIP2-depletion mode of neuronal IM suppression, and is disrupted by calmodulin.
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