抗氧化剂干预间歇低氧对中性粒细胞凋亡影响的研究

来源 :The Third Internaitional Conference on Respiratory Diseases( | 被引量 : 0次 | 上传用户：weilove721

【摘要】

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【作者】

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呙恒娟陈宝元李津娜杨晓燕姜君男

【机构】

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天津医科大学总医院呼吸科 300052

【出处】

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The Third Internaitional Conference on Respiratory Diseases(

【发表日期】

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2013年2期

【关键词】

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间歇低氧中性多核白细胞凋亡内皮细胞羟基-2 2 6 6-四甲基哌啶

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　　目的探讨间歇低氧(lH)对大鼠中性多核细胞(PMN)凋亡的影响及抗氧化剂的干预作用.材料与方法 24只雄性Wistar大鼠分为常氧对照组(NC)、间歇低氧组(IH)、间歇低氧Tempol干预组(IHT)和间歇低氧盐水干预组(IHN),每组6只.IH组最低氧浓度为5％,低氧频率为30次/h,8 h/d.暴露6周后处死大鼠,分离纯化PMN.用抗体标记中性粒细胞,流式细胞术检测凋亡.结果 NC组、IH组、IHT组和IHN组中性粒细胞凋亡率分别为28.10％、15.90％、33.44％、27.06％.IH组与NC组比较,中性粒细胞凋亡率明显减少,凋亡延迟,差异有统计学意义(均P＜0.05).IHT组与IH组、NC组相比较,差异有统计学意义(均P＜0.05).

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抗氧化剂干预间歇低氧对中性粒细胞凋亡影响的研究

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