Methylation of DACT2 accelerates esophageal cancer development by activating Wnt signaling

来源 :2015中国转化医学大会暨中国转化医学联盟成立大会 | 被引量 : 0次 | 上传用户：yinyueemo1122334

【摘要】

：

　　Esophageal cancer is one of the most common malignancies worldwide.DACT2 is frequently methylated in human lung, hepatic, gastric and thyroid cancers.The me

【作者】

：

MeiyingZhang[1]EnqiangLinghu[2]QiminZhan[3]TaoHe[2]BaopingCao[2]MalcolmV.Brock[4]JamesG.Herman[5]RongXiang[6]MingzhouGuo[2]

【机构】

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中国人民解放军总医院

【出处】

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2015中国转化医学大会暨中国转化医学联盟成立大会

【发表日期】

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2015年期

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　　Esophageal cancer is one of the most common malignancies worldwide.DACT2 is frequently methylated in human lung, hepatic, gastric and thyroid cancers.The methylation status and function of DACT2 remain to be elucidated in human esophageal cancer.Ten esophageal cancer cell lines and 140 cases of primary esophageal cancer samples were analyzed in this study.

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Methylation of DACT2 accelerates esophageal cancer development by activating Wnt signaling

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