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Objective To explore the effect of differentaltitude on sleep apnea-hypopnea of Han Nationality and Uyghur Nationality.Methods 288 subjects were underwent respiration and pulse oximeter tests.Apnea-hypopnea index(AHI), hypopnea index (HI),mean SaO2(MSaO2%), the lowest SaO2(LSaO2%),the time spent at SaO2 below 90%, the number of desaturations≥4% per hour(ODI4) were calculated at different altitude district(Keramay city altitude 500m and Kunming city altitude1890m).