Inflammation has been found to play a major role in breast cancer development through the activation of transcription factor NF-κB.NF-κB, a transcription factor, is present normally in the cytoplasm as an inactive heterotrimer consisting of p50, p65 and 1κBα subunits.When activated, NF-κB trartslocates to the as a p50-p65 heterodimer.NF-κB has been linked to the development of breast cancer for several reasons.