Cancer,trauma,and congenital defects can produce tissue deficits in the craniomaxillofacial complex that are associated with severe esthetic deformity,discomfort,and functional impairment.In particular,tumors that require high dose chemoradiation and extensive resection often leave behind tissues that have limited vascularity,significant scarring,and poor healing capacity.While the use of vascularized free flaps can improved graft survival in these suboptimal healing environments,strategies to minimize tissue damage are highly desirable to maximize the remaining quality of life.This talk will highlight recent bioengineering advances that may be useful in the preservation of critical tissues surrounding unresectable tumors.This talk will also summarize some of the exciting innovations in reconstructive biotechnology that may be used to promote the regeneration of functional anatomical structures in the craniomaxillofacial complex.