The imbalance expressing of Cu/Zn superoxide dismutase (SOD1) in vivo will cause intracellular oxygen reduction signal to disorder, which leads to cell proliferation, tumorigensis and damage motorneur
Polypeptide drugs cause increasing attention due to their application in clinical treatment.On the one hand, many linear peptides have good stability and biological activity in vitro, they degradate r
The PDBbind database is created to provide a comprehensive collection of the binding data for the biomolecular complexes deposited in the Protein Data Bank (PDB).It thus provides a link between energe
A series of novel halogenated 1-benzyl-1-ethyl-3-phenylthiourea derivatives were synthesized by reacting isothiocyanatobenzene and some halogenated N-benzylethanamine.All these compounds have been cha
G-Quadruplex, differing from other DNA structures like duplex structures, hairpin, triplex, and i-motif structures, is formed by human DNA sequences that consist of tandem guanine (G) nucleotides fold
MnSOD is thought to be essential in a series of CNS disorders including Alzheimers disease, Parkinsons disease, stroke and etc.Various therapeutic strategies have been developed, especially synthesize