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5. Synthesis and DNA-cleaving Activities of Cu(Ⅱ) Complexes of Pyrrole-polyamide Dimers Tethered with E

Synthesis and DNA-cleaving Activities of Cu(Ⅱ) Complexes of Pyrrole-polyamide Dimers Tethered with E

来源 :第十届国际华人无机化学研讨会 | 被引量 : 0次 | 上传用户：xxxmmm1236

【摘 要】

：

Two new Cu(Ⅱ) complexes of C2-symmetrical dimers of monopyrrole-polyamide 2 and dipyrrole-polyamide 6 tethered with EDTA analogue (i.e., Cu-2 and Cu-6), were f

【作 者】

：

Jianwei Yang Yanling Lin Chen Dong Wenhua Chen Chunqiong Zhou 

【机 构】

：

SchoolofPharmaceuticalSciences,SouthernMedicalUniversity,Guangzhou510515

【出 处】

：

第十届国际华人无机化学研讨会

【发表日期】

：

2014年12期

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论文部分内容阅读

Two new Cu(Ⅱ) complexes of C2-symmetrical dimers of monopyrrole-polyamide 2 and dipyrrole-polyamide 6 tethered with EDTA analogue (i.e., Cu-2 and Cu-6), were found to be capable of efficiently converting pBR322 DNA into open circular and linear forms under physiological conditions, most probably via an oxidative mechanism.

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