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The microstructure evolution during the homogenization heat treatment of Al-Mg-Si-Fe-Mn, or AA6xxx, alloys has been investigated using a combination of modelling and experimental studies.The model is based on the CALPHAD-coupled two-scale homogenization heat treatment model originally developed for AA3xxx alloys (i.e.Al-Mn-Fe-Si).In this work, the model has been adapted to the more complex AA6xxx system (Al-Mg-Si-Mn-Fe) to predict the evolution of critical microstructural features such as the spatial distribution of solute, the type and fraction of constituent particles and dispersoid number density and size distribution.