【摘 要】
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Objective: To determine whether As2O3 affects the demethylation of the SHZ domain-containing protein tyrosine phosphatase (SHP-1) and the proliferation and apoptosis of cutaneous T-cell lymphoma cell
【机 构】
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Department of Hematology and Blood and Marrow Transplantation,Tianjin Medical University Cancer Inst
【出 处】
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22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会)
论文部分内容阅读
Objective: To determine whether As2O3 affects the demethylation of the SHZ domain-containing protein tyrosine phosphatase (SHP-1) and the proliferation and apoptosis of cutaneous T-cell lymphoma cell lines, as well as to elucidate its mechanism of action.Methods: The activity ofAs2O3 was analyzed in two cutaneous T-cell lymphoma cell lines, including HuT 78 and HuT 102,and cells derived from cutaneous T-cell lymphoma patients.All cells were treated with As2O3 at different concentrations (2.5, 5,and 7.5 μmol/L) and different incubation times (24, 48, and 72h).The methylation status of SHP-1 promoter and the changes in methylation status after As2O3 treatment in the cells were detected by methylation specific polymerase chain reaction(MSP).
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