【摘 要】
：
Background:To assess the antiviral efficacy of lamivudine(LAM),entecavir(ETV),telbivudine(LDT),and lamivudine and adefovir dipivoxil(CLA) combination in previously untreated hepatitis B patients at di
【机 构】
：
Department of Infectious Disease,the First Affiliated Hospital of Anhui Medical University
【出 处】
：
2014年APASL专题会议暨第四届乙型病毒性肝炎专题会议
论文部分内容阅读
Background:To assess the antiviral efficacy of lamivudine(LAM),entecavir(ETV),telbivudine(LDT),and lamivudine and adefovir dipivoxil(CLA) combination in previously untreated hepatitis B patients at different time points during a 52-week treatment period.Methods:A total of 164 patients were included in this prospective,open-label,head-to-head study.Serum levels of alanine transaminase(ALT),hepatitis B virus(HBV) DNA,and hepatitis B e antigen(HBeAg) were measured at baseline,and at 12,24,and 52 weeks of treatment.
其他文献
Background:The interplay of virus/host proteins mediates the hepatitis B virus(HBV) infection.Host factors may provide new targets for the antiviral therapy of HBV infection.Autophagy plays a vital ro
Objective:To evaluate the antiviral efficacy and safety of telbivudine(LDT) and entecavir(ETV) in patients with chronic hepatitis B(CHB) after IFN treatment failure.
Aims:This study aimed to compare virological response of entecavir monotherapy and de novo lamivudine plus adefovir combination therapy in chronic hepatitis B(CHB) patients with high viral load.
Objective:To investigate whether the prognostic simple model for evaluating patients with severe hepatitis based on platelet and hepatic function be of practical value.
Hepatitis B infection is a major etiology of acute and chronic hepatitis,cirrhosis,and hepatocellular carcinoma(HCC) in Korea,suggesting that HBV infection greatly affects public health of Korea.Curre
Background:To characterize deletion/insertion(Del/Ins) mutations in hepatitis B virus(HBV) whole genome sequences at antiviral baseline and to reveal their potential impacts on nucleos(t)ide analogue
Background:Anti-viral therapy is important in advanced liver fibrosis/cirrhosis with chronic hepatitis B(AdLFCHB) patients,but complete regression of cirrhosis remains to be challenge.
Background:The aims of this study are to clarify the relations among the serum alpha-fetal protein(AFP) from normal range to obvious high level and liver histological inflammation grades,as well as st
Background:Hepatitis B virus(HBV) genotypes vary in their geographical distribution and virological features.Previous investigations have shown that HBV genotype B is a predominant HBV genotype in Chi
Background:The role vitamin D playing in patients with
chronic hepatitis C has been intensively studied.However.studies on the potential interaction between vitamin D level and chronic hepatitis B ar