A comparative analysis reveals the dosage sensitivity and regulatory patterns of lncRNA in breast ca

来源 :第七届全国生物信息学与系统生物学学术大会 | 被引量 : 0次 | 上传用户:kxsaqq
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  In recent years,the research on lncRNA is increasing sharply,cumulative reports have suggested that lncRNA is involved in many biological processes of diseases such as cancer.Here,we present a comprehensive study that demonstrates the impact of miRNA-TF co-regulatory motifs on the dosage effects of protein-coding genes (PCGs) and lncRNAs,in breast cancer(BRCA).
其他文献
Nucleosome has been a extensively studied topic not only because its position affects directly cellular processes,such as DNA replication,recombination,and transcription,but also because it severs as
Transglutaminase (TGase) is an important multifunctional enzyme,which catalyzes acyl transfer reactions between the γ-carboxyamide group of a peptide bound glutamine residue and the ε-amino group of a
Hepatitis B virus (HBV) infection remains a severe global health issue causing hepatitis or hepatocellular carcinoma.Other study confirmed that DNA methyltransferase genes (DNMTS)were unregulated and
Breast cancer is one of common malignant rumors.The DNA methylation plays a very important role in breast cancer (BC).Understanding methylation abnormalities is significant for improving diagnosis and
DNA methylation is an important molecular mechanism in regulation of gene expression.It is relevant to the development of lung cancer and is molecular biomarker for lung cancer.DNA methylation biomark
MethBank is a database that integrates whole-genome single-base nucleotide methylomes and provides an interactive browser for visualization of high-resolution DNA methylation data.Here we present an u
Objective: To construct the pEGFP-C1-Sam68 eukaryotic expression vector and establish a cell line stably expressing pEGFP-C 1-Sam68.Methods: Sam68 amplified by PCR,and identified by electrophoresis an
Some pseudogenes have been reported to play important roles in gene regulation,but little is known about the evolutionary direction of pseudogenes at population level as well as the possible relations
Transcription factors and epigenetic modifications plays an important role of gene expression,and also some more experimental phenomena have been discovered this phenomenon.However,in the experiment,T
It is known that chromatin three-dimensional (3D) structure plays important roles in nucleus.Recently,the extensive works from chromosome conformation capture (3C) derived techniques,such as Hi-C,have