Obesity is a low-grade chronic proinflammatory state,and adipose tissue is one of the insulin targets as the key link of obesity and insulin resistance.More than 50 %of the interstitial cells in adipo
罗格列酮是PPARγ的特异性激动剂,广泛用于Ⅱ型糖尿病的临床治疗。然而大量的临床研究显示,长期使用该药物的患者,其骨量丢失严重,骨折发生率显著提高。实验室研究也显示,罗格列酮能够抑制骨形成,然而具体作用机制尚未阐明。
Objective:Nesfatin-1,an anorexigenic peptide involved in energy homeostasis.Recently,peripheral nesfatin-1 was reported to participate in the development of T2DM and stimulated free fatty acid.The mai
Renal transplantation is the treatment of choice for end-stage renal failure.Although acute rejection is not a major issue anymore,chronic rejection is still a major factor that might lead to allograf
Background:Prior experimental and epidemiologic data support a link between exposure to fine ambient particulate matter (<2.5 μm in aerodynamic diameter,PM2.5) and development of insulin resistance/Ty
目的:探讨转化生长因子-β(TGF-β)在年龄相关性黄斑变性(AMD)致脉络膜新生血管形成(CNV)中的作用。方法:将周龄为6-8W 的健康雄性C57BL/6J 小鼠,分为正常对照、光凝制备AMD 模型、光凝+PBS 对照和光凝+TGF-β 受体抑制剂等四组(每组n=20)。
We previously demonstrated that conventional protein kinase C (cPKC)γ was involved in hypoxic preconditioning (HPC)-induced neuroprotection against ischemic injuries of mice with middle cerebral arter
The outbreak and maintenance of green tides made of Enteromorpha prolifra associates closely with the nutrient.To determine the nutrient strategy to guarantee nutrient demand of vast biomass when the
水母暴发已成为一种新型海洋生态灾害,对海洋生态系统的结构和功能平衡、渔业资源、滨海电厂生产安全、海洋景观和旅游业均有着巨大影响.近年来,我国黄海和东海北部区域是水母暴发发生的高风险区域.本文总结了黄海和东海北部区域水母暴发的研究成果,阐述了构成水母暴发种类的组成、分布、生活史特征及其危害,分析了水母暴发的可能诱因,并探讨了水母灾害的监测及防控技术,为水母灾害的监测、管理和应急处置提供科学依据.
深圳河是深圳与香港的界河,属于感潮河流,感潮河段13.11 km,干流盐度变化明显.近五年深圳河水质调查参数表明,其富营养化问题突出,NH4+等营养盐指标已超出地表水Ⅴ类标准若干倍,严重影响水体功能,亟需治理.生态浮床技术是近些年发展起来的水体净化技术,已成功应用于湖泊、城市河道、水库等水体的修复,尤其对富营养化水体具有较好的净化效果,备受业内人士亲睐.通过对深圳河的水文潮流条件以及其感潮特性进行