Drug release mechanisms of chemically cross-linked albumin microparticles: effect of the matrix eros

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  One of the most promising areas of particles is the research and development of new pharmaceutical formulations,being that the main application is aimed towards the drug delivery.Among the various materials used in the production of nano and microparticles,there has been a considerable interest in the proteins as a starting substance for synthesis of more sophisticated release systems that may preserve the molecular structure of more potent and specific drugs [1].Both bovine serum albumin (BSA) and human serum albumin (HSA) are used in the production of nano/microparticles [1,2] in view of their structural similarity that corresponds to 75 %of the homologous sequence.BSA is more suitable for in vivo tests due to its lower cost.
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