【摘 要】
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I will present our recent work on the following two classes of mutant proteins: 1) Androgen receptor (AR) is a current drug target for advanced prostate cancer.However, a series of mutated ARs were ch
【机 构】
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Departments of Oncology and Medicine, McGill University, Segal Cancer Centre-Lady Davis Institute, S
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I will present our recent work on the following two classes of mutant proteins: 1) Androgen receptor (AR) is a current drug target for advanced prostate cancer.However, a series of mutated ARs were characterized from tissue specimens of prostate cancer and found to cause drug resistance.For example, antiandrogen bicalutamide is an inhibitor of the wild type AR, but becomes an activator of the W741C mutated AR.Whats more, multiple AR mutants can be found in the same patients.
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