Nonlinear Analgesic Mechanisms of Sodium Channel Modulators from Scorpion Venom

来源 :The 6th Asian Pain Symposium, APS 2015(第六届亚洲疼痛研讨会) | 被引量 : 0次 | 上传用户：zcat16

【摘要】

：

　　BmK IT2, a site-4-specific modulator of VGSCs, significantly suppressed the formalin-induced rat spontaneous flinches and spinal c-Fos expression in a dose-

【作者】

：

YonghuaJi;

【机构】

：

Shanghai University, China

【出处】

：

The 6th Asian Pain Symposium, APS 2015(第六届亚洲疼痛研讨会)

【发表日期】

：

2015年期

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　　BmK IT2, a site-4-specific modulator of VGSCs, significantly suppressed the formalin-induced rat spontaneous flinches and spinal c-Fos expression in a dose-dependent manner.Binding assay of 125I-BmK IT2 showed two non-interacting binding sites on insect neuronal membranes: a high affinity (Kd1=0.65±0.20 nM) and low capacity (Bmax1=0.46±0.13 pmol/mg protein) binding site, as well as a low-affinity (Kd2=78.7±16.4 nM) and high capacity (Bmax2=33.1±8.5 pmol/mg protein) binding site.

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Nonlinear Analgesic Mechanisms of Sodium Channel Modulators from Scorpion Venom

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