Peripheral pain is enhanced by insulin-like growth factor 1 through a G rotein-mediated stimulation

来源 :The 6th Asian Pain Symposium, APS 2015(第六届亚洲疼痛研讨会) | 被引量 : 0次 | 上传用户：chiivy

【摘要】

：

　　Insulin-like growth factor 1 (IGF-1) is implicated in the nociceptive (pain)sensitivity of primary afferent neurons.We found that the IGF-1 receptor (IGF-1R

【作者】

：

JinTao;

【机构】

：

Soochow University, China

【出处】

：

The 6th Asian Pain Symposium, APS 2015(第六届亚洲疼痛研讨会)

【发表日期】

：

2015年期

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　　Insulin-like growth factor 1 (IGF-1) is implicated in the nociceptive (pain)sensitivity of primary afferent neurons.We found that the IGF-1 receptor (IGF-1R)functionally stimulated voltage-gated T-type Ca2+ (CaV3) channels in mouse dorsal root ganglia (DRG) neurons through a mechanism dependent on heterotrimeric G protein (heterotrimeric guanine nucleotide-binding protein) signaling.

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Peripheral pain is enhanced by insulin-like growth factor 1 through a G rotein-mediated stimulation

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