下调GnT-V通过调节药物转运蛋白hENT1 N-糖基化促进膀胱癌细胞吉西他滨药物敏感性

来源 :2014年全国糖生物学学术会议 | 被引量 : 0次 | 上传用户：blzzb001

【摘要】

：

N-乙酰氨基葡萄糖转移酶V (GnT-V)是催化糖蛋白上β 1,6-N-糖链分支结构形成的关键酶,与肿瘤的发生、发展密切相关,然而其在肿瘤细胞药物敏感性中的作用尚待研究.人平衡型核苷转运蛋白1 (human equilibrative nucleoside transporter 1,bENT1)是胞外区含有多个N-糖基化点、11次穿细胞膜的跨膜糖蛋白,是膀胱癌化疗一线药物吉西他滨的主要转运载体蛋

【作者】

：

樊建慧靳利远唐颖董伟杰何静娜汪淑晶柳林华王莉芬房德玉张嘉宁

【机构】

：

大连医科大学生物化学与分子生物学教研室糖生物学研究所辽宁省大连市116044 大连理工大学生命科

【出处】

：

2014年全国糖生物学学术会议

【发表日期】

：

2014年8期

【关键词】

：

N-乙酰葡糖胺基转移酶V N-糖基化人平衡型核苷转运蛋白1 膀胱癌

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下调GnT-V通过调节药物转运蛋白hENT1 N-糖基化促进膀胱癌细胞吉西他滨药物敏感性

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