【摘 要】
:
How glucose is metabolized can influence cell function,but whether differences in energy metabolism reflect,or dictate,cell state is not clear and is of particular interest given the association of ca
【机 构】
:
Center for Regenerative Medicine,Massachusetts General Hospital,Boston,MA 02114 USA;Harvard Stem Cel
论文部分内容阅读
How glucose is metabolized can influence cell function,but whether differences in energy metabolism reflect,or dictate,cell state is not clear and is of particular interest given the association of cancer with aerobic glycolysis.
其他文献
Circadian rhythms have been strongly implicated in mood disorders and other neuropsychiatric disorders.But the actual genes and related regulatory mechanisms remain to be found.In this study, we aim t
Many previous studies have established the link between aberrant microRNAs pattems and hypoxia in various solid tumors.However, how these hypoxia-related microRNAs modulate tumor progression is still
Upstream open reading frame(uORF) is one of the post-transcriptional regulatory elements in the 5UTR, which modulates the translation levels of its downstream main coding sequence, namely main ORF(mOR
Light is an important environmental signal that affects diverse plant growth and developmental processes through a complicated signaling transduction pathway.Chromatin remodeling plays a central role
目的:探讨染色体结构异常携带者孕妇的妊娠生育风险及遗传咨询要点.方法:对22例夫妻一方为染色体结构异常携带者的孕妇进行羊水穿刺及胎儿染色体核型分析,并对妊娠结局进行随访.结果:22例携带者中女性20例,男性2例,其中平衡易位携带者14例,占63.6%;罗伯逊易位携带者6例,占27.3%;臂间倒位2例,占9.1%.胎儿染色体核型结果正常7例(1例1qh+划入正常范围),占31.8%;易位及倒位携带者
杂合性缺失(Loss of heterozygosity, LOH)指某个基因座上的一个等位基因出现杂合缺失,或两个等位基因来自同一个亲本所导致的纯合现象.杂合性缺失大多数临床意义不明,但需警惕该区域内隐性遗传基因、印记基因的致病风险.当患者出现与该区域内隐性遗传基因、印记基因相关的临床表型时,需对相应的基因作进一步检测.地中海贫血(简称地贫,Thalassemia),是一种常染色体隐性遗传溶血性
目的:探讨一种新的基于CNVplex技术的高效耳聋基因筛查平台的临床应用实践.方法:(1)采用CNVplex技术,选择非综合征耳聋(Non-syndromic hearing loss,NSHL)患者中突变率达60%以上的GJB2、SLC26A4、mt-DNA三个基因在中国人群中报道的115个突变型(其中GJB2基因36种突变型,SLC26A4基因77种突变型,mt-DNA基因2种突变型),通过常
目的 探讨多重连接依赖式探针扩增(Multiplex ligation-dependent probe amplification,MLPA)技术性在临床上检测先天性心脏病(congenital heart defects,CHDs)患者基因拷贝数变异(Copy number variation,CNV)的可行性,了解中国未挑选的先天性心脏病患儿中基因拷贝数变异的发生情况.方法 收集未挑选的125
目的:遗传性多发性骨软骨瘤(hereditary multiple exostoses,MO),是一种骨胳发育异常,在骨胳上可形成大小不等的骨隆起的常染色体显性遗传性疾病.本研究利用一个多发性遗传性骨软骨瘤大家系进行致病基因的突变鉴定.方法:遵守知情同意原则,采集到1个6代家系共计25份外周血标本,其中患者18人,正常个体7人,涉及三代.明确患病表型和临床诊断,分别在已知EXT1,EXT2致病候选
In mammals,mTOR is the key component of two distinct multi-protein complexes,mTOR complex 1 (mTORC1) and 2 (mTORC2).mTORC2 is insensitive to rapamycin and includes mTOR,Rictor,mLST8,mSin1,Protor-1,and