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  5. The RNA Binding Protein Sam68 Enhances Exon 7 Inclusion Guring the Survival of Motor Neuron Pre-mRNA

The RNA Binding Protein Sam68 Enhances Exon 7 Inclusion Guring the Survival of Motor Neuron Pre-mRNA

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：leovvex
【摘 要】
：
Background: Spinal muscular atrophy (SMA) is a motor neuron disease caused by deficiency of the ubiquitous survival motor neuron (SMN) protein.But essential, levels of SMN protein are produced by the
【作 者】
：
高春艳 李珺 赵秀娟 蔡禄 
【机 构】
：
数理与生物工程学院,内蒙古科技大学,包头,014010 数理与生物工程学院,内蒙古科技大学,包头,
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年4期
【关键词】
：
Spinal Muscular Atrophy (SMA) Alternative splicing SMN-Minigenes Sam68 proteins 
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　　Background: Spinal muscular atrophy (SMA) is a motor neuron disease caused by deficiency of the ubiquitous survival motor neuron (SMN) protein.But essential, levels of SMN protein are produced by the nearly identical gene SMN2.The human SMN2 gene has a C-to-T transition at position +6 of exon 7 and thus produces exon 7-inclusion.
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