The complementary role of ATM and ATR in synaptic vesicle dynamics

来源 :The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern | 被引量 : 0次 | 上传用户:zhangdong1231
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Ataxia telangiectasia mutated (ATM), a high molecular weight PI3K-family kinase,is a predominantly nuclear protein involved in the early recognition and response to DNA double-strand breaks.In addition these nuclear functions, ATM is also well recognized for several diverse roles in the neuronal cytoplasm, including important features of vesicle trafficking.
其他文献
The ATR-Chk1 pathway is critical for DNA damage responses and cell cycle progression.Chk 1 inhibition is more deleterious to cycling cells than ATR inhibition,raising questions about ATR and Chk1 func
会议
As replication forks move across chromatin DNA, they frequently stall at hundreds to thousands of intrinsic replication barriers and DNA lesion sties.Stalled forks must require intra-S phase checkpoin
会议
DNA damage response (DDR), an essential singling cascade for genome integrity, must be strictly regulated as either loss of, or augmented DDR leads to unintended consequences of cell fates.Here, we id
会议
The ATR pathway controls chromosome integrity and chromatin dynamics.We recently found that ATR, ATRIP and Chk1 associate to the nuclear envelope during S phase and prophase and in response to mechani
会议
Although we know a great deal about DNA DSB repair pathways in general, very little is known about how DSB repair is affected by its natural context in the cell, that is, within chromatin.Chromatin st
会议
A broad repertoire of modifications is known to underlie adaptable coding and structural function of proteins, DNA and various RNA species.Methylations of mammalian DNA and histone residues are known
会议
The ATM protein kinase is implicated in the DNA damage response and in sensing DNA double strand breaks.However, recent observations have involved ATM in non-nuclear pathways.ATM belongs to the PIKK f
Ataxia-telangiectasia (A-T) is a neurodegenerative disease with autosomal recessive inheritance and, despite being monogenic, is characterized by a very pleiotropic phenotype.Since the major functions
The primary cause of A-T is ATM mutations.The ATM protein is a multifunctional,homeostatic protein kinase with a major role in maintaining genome stability, primarily in the response to DNA double-str
Ataxia Telangiectasia is a rare autosomal recessive neurodegenerative disorder caused by mutation in the ATM gene.Identification of mutations is challenging, since they are scattered throughout the ge