2. 您的位置
3. 首页
4. 会议论文
5. 成人隐匿性自身免疫性糖尿病(LADA)与TCF7L2基因研究

成人隐匿性自身免疫性糖尿病(LADA)与TCF7L2基因研究

来源 :第八届湘雅国际糖尿病免疫学论坛 | 被引量 : 0次 | 上传用户：chubiao5201314

【摘 要】

：

目的 探讨TCF7L2基因rs7903146和rs12255372单核苷酸多态性与LADA的相关性.方法 采用病例-对照研究方法,收集99例正常人、47例LADA患者和100例2型糖尿病患者的临床资料,采集空腹时静脉血进行甘油三酯、胆固醇、空腹血糖、空腹胰岛素检测,并计算体重指数、稳态胰岛素抵抗指数(HOMA-IR)和稳态细胞β功能指数(HOMA-β),同时进行全血DNA提取、目的片段PCR扩增、

【作 者】

：

吴贻竞 邓志明 

【机 构】

：

常德市第一人民医院内分泌科 415000

【出 处】

：

第八届湘雅国际糖尿病免疫学论坛

【发表日期】

：

2013年4期

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

目的 探讨TCF7L2基因rs7903146和rs12255372单核苷酸多态性与LADA的相关性.方法 采用病例-对照研究方法,收集99例正常人、47例LADA患者和100例2型糖尿病患者的临床资料,采集空腹时静脉血进行甘油三酯、胆固醇、空腹血糖、空腹胰岛素检测,并计算体重指数、稳态胰岛素抵抗指数(HOMA-IR)和稳态细胞β功能指数(HOMA-β),同时进行全血DNA提取、目的片段PCR扩增、 rs12255372单核苷酸基因克隆并应用Maxam-Gilbert DNA化学降解法对rs7903146和rs12255372进行直接基因测序和多态性检测.

其他文献

The association between IFIH1 gene rs1990760 polymorphism and susceptibility to type 1 diabetes: a m

Objective To explore comprehensively the relationship between IFIH1 gene rs1990760 polymorphism and susceptibility to type 1 diabetes (T1DM).Methods References were retrieved through the computerized

会议

Hepatic ZBTB20 regulates lipid metabolism and insulin sensitivity

Hepatic lipogenesis is regulated by dietary carbohydrates, and have a critical role in the development of hepatic steatosis and insulin resistance.Here we show that the novel zinc finger protein ZBTB2

会议

Molecular mechanisms underlying amino acid regulation of metabolism

We recently discovered that mice repress fatty acid and triglyceride synthesis in the liver and mobilize fat stores from abdominal adipose tissue maintained on a diet deficient for an essential amino

会议

Dipeptidyl Peptidase 4 Inhibitor Sitagliptin Preserves β-Cell Function in Patients with Recent-Onset

Objective To investigate the effects of DPP-4 inhibitor on β-cell function in patients with latent autoimmune diabetes in adults (LADA).Research design and methods Thirty newly diagnosed LADA patients

会议

FGF21 and adiponectin act in concert to confer the metabolic actions of adipocyte on glucose metabol

Fibroblast growth factor (FGF) 21 is a metabolic hormone with pleiotropic effects on regulating glucose and lipid homeostasis and insulin sensitivity.It plays an indispensable role in mediating the th

会议

The expression and methylation pattern of regulatory sequence of IL-17 gene in CD4+T cells from pati

Objective To investigate the expression level and methylation pattern of IL-17 gene in CD4 T+ cells from patients with latent autoimmune diabetes of adults and healthy controls.Methods PBMCs were isol

会议

Targeting insulin resistance in type 2 diabetes via immune modulation of cord blood-derived multipot

The prevalence of type 2 diabetes (T2D) is increasing worldwide and creating a significant burden on health systems, highlighting the need for the development of innovative therapeutic approaches to t

会议

The Role of TRIF in the Development of Type 1 Diabetes (T1D)in Nonobese Diabetic Mice

TIR-domain-containing adapter-inducing interferon-β (TRIF) is an adaptor for activation of some Toll Like Receptors (TLRs).It mediates one of two TLR-associated signaling cascades, where TRIF mediates

会议

Serum Metabolic Signatures of Fulminant Type 1 Diabetes

Aim: Fulminant type 1 diabetes (FT1DM) is a relatively new clinical entity featured by acute destruction of pancreatic beta cells.Clinical consequences of FT1DM could be fatal when timely medications

会议

短期去除B细胞对糖尿病致病性T细胞的影响

hCD20NOD是一种B细胞表达人CD20的拟人化转基因小鼠, 因此使用抗人的CD20单抗-2H7可以将小鼠的B细胞去除.BDC2.5NOD小鼠是一种TCR转基因小鼠,其TCR特异性识别胰岛抗原,可被人工合成抗原mimotope特异性激活,其淋巴细胞过继到免疫缺陷(SCID)小鼠后可迅速诱发自身免疫糖尿病.

会议