【摘 要】
:
The pregnane-X-receptor (PXR) regulates the expression of biotransformation enzymes and transporters for drugs and steroid hormones.Thereby, it influences c
【机 构】
:
Department of Pathophysiology Medical University of Vienna Austria
论文部分内容阅读
The pregnane-X-receptor (PXR) regulates the expression of biotransformation enzymes and transporters for drugs and steroid hormones.Thereby, it influences cell proliferation and tumor growth.In hormone-sensitive tumor cells, PXR regulates estrogen homeostasis by targeting phase Ⅰ biotransformation enzymes., hormone-inactivating sulfotransferases (SULTs), ATP-dependent drug efflux pumps (e.g.P-glycoprotein, ABCG2), and uptake transporters from the organic anion transport polypeptide family OATP.
其他文献
This study is concerned with the class of gravity-capillary lumps recently found on water of finite or infinite depth for Bond number, B < 1/3.In the near-l
The thyroid hormone receptor alpha (TRα), a transcription factor which is essential for normal development, growth, and homeostasis, either activates or re
The fundamental properties of a spinor Bose-Einstein condensate (BEC) are deter mined by both spin-exchange and dipole interactions.The spin-dependent part
F INTRODUCTION:Hypercholesterolemia is one of the important paraneoplastic syndromes in patients with hepatoma(s), but the nature of the defect has not been
Glioblastoma multiforme is histologically and genetically heterogeneous lesion, which is the most common malignant tumor of the central nervous system in ad
做丁小平的弟子需要绝对忠诚、可靠,无条件地拥护信任他“中华大学生自我完善夏令营”实际报名者约为120多人,在已经报到的80人当中,营员大概分为几类:最受信任的“创新讨论
The steroid Receptor RNA Activator (SRA) was originally identified as a non-coding RNA able to specifically enhance the activity of steroid receptors.Additi
The discovery and characterization of novel groups of proteins (cofactors) that participate in the transcriptional activity of nuclear receptors (NRs) have
11月1日晚,首创资产、白云生活广场、蓝图地产机构在翠宫饭店举行产品说明会,正式推出白云生活广场项目,并打出朝阳路商业航母的旗号。白云生活广场位于朝阳路中段。朝阳路不