【摘 要】
：
Rheumatoid arthritis (RA)is a chronic and progressive systemic inflammatory arthropathy characterized by synovial hyperplasia inflammation, cartilage loss and bone destruction.As we know, aberrant act
【机 构】
：
School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products,Anhui Medical University
【出 处】
：
中国药理学会生化与分子药理专业委员会2014年研讨会
论文部分内容阅读
Rheumatoid arthritis (RA)is a chronic and progressive systemic inflammatory arthropathy characterized by synovial hyperplasia inflammation, cartilage loss and bone destruction.As we know, aberrant activation of fibroblastlike synoviocytes(FLS) play an important role in both initiation and perpetuation of synovitis and joint destruction in the progression of RA.Accroding to the report and the known attributes of Wnt/β-catenin pathway, one might rationalize that untimely activation of Wnt/β-catenin pathway in RA FLS is partly responsible for-driving RA FiS activation and RA pathogenesis.MicroRNAs(miRNA) are a class of i9-23 nucleotide-long short endogenous, single-stranded, noncoding RNAs and control numerous basic biologic functions including cell cycle, cellular differentiation proliferation, and apoptosis.
其他文献
目的:结肠癌的发病率及死亡率在我国呈逐年上升的趋势,且趋于年轻化.部分患者在确诊结肠癌时已发生肝转移,约60％～71％的结肠癌患者最终发生肝转移导致死亡.大量研究证实结肠癌干细胞是导致结肠癌发生发展、转移复发、放化疗抵抗的源泉.目前,靶向结肠癌干细胞的治疗还没有取得突破性进展.5-氟尿嘧啶(5-Fu)是结肠癌化疗的常用药物,然而5-Fu毒副反应大限制了其在临床的广泛应用.普朗尼克(Pluronic
Aim: Platinum-based chemotherapy is the main treatment method in lung cancer patients.The genetic polymorphism of Wnt inducible signaling pathway protein l(WISP1)was reported to be associated with the
目的:已有研究表明新癀片具有显著的抗炎镇痛作用,本研究主要是利用蛋白组学找出与抗炎镇痛作用相关的差异表达蛋白,确定药物作用的通路和靶点,在蛋白质水平上进步分析新癀片的抗炎镇痛作用机制.方法:选用SD雄性大鼠,随机分成6组,分别为对照组、模型组、吲哚美辛组、新癀片高剂量组、中剂量组和低剂量组,除对照组外,、在大鼠右后足垫部皮下注射角叉菜胶浆致炎.测定致炎前和致炎后1、2小时右后肢踝关节下方0.5cm
目的:本试验以CC14诱导的肝纤维化大鼠为试验模型,利用基因芯片技术观察丹参滴丸对肝纤维化大鼠肝组织基因表达的影响.方法:除对照组外,其余各组大鼠用CC14复合因素法诱导肝纤维化大鼠模型,丹参滴丸各组同时ig给予丹参滴丸700、350、175 mg/kg,每天给药1次,连续给药7周,利用基因芯片技术测定肝组织的基因表达,运用dchip分析软件寻找差异表达基因,探讨丹参滴丸抗肝纤维化的作用机制.结果
Macrophages are characterized by remarkable plasticity, and they can undergo their phenotypically/functionally dynamic switch in response to exposure to various microenvironrnental signals.These chang
Hesperidin is a flavanone glycoside extracted from fruits of the genus citrus.For it poor solubility, our lab have synthesis a lot of derivatives.Previous studies were focus on the inflammation role o
Objective: To study whether miR-20a belonging to the cluster miR-17-92 is a negative regulator of The NOD-like receptor family, pyrin domaincontaining 3 (NLRP3)inflammasome in rheumatoid arthritis(RA)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)is a new member of thec tumor necrosis factor superfamily, and induces apoptosis and inflammation.However, whether ER stress has any effe
Therapeutic management of liver fibrosis remains an unsolved clinical problem.Hepatic accumulation of extracellular matrix(ECM), mainly collagen, is mediated by the production of transforming growth f
Hepatic stellate cell(HSC) activation is a significant event in the development of liver fibrosis.Enhance the activated HSC apoptosis contributes to the reversal of liver fibrosis.Autophagy is conside