【摘 要】
：
Pleomorphic Adenoma Gene 1 (PLAG1) is the founding member of a subfamily of zinc finger transcription factor genes.PLAG1, on human chromosome 8q12, encodes an essentially developmentally regulated pro
【机 构】
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Laboratory for Molecular Oncology Department of Human Genetics University of Leuven Belgium
【出 处】
：
BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会)
论文部分内容阅读
Pleomorphic Adenoma Gene 1 (PLAG1) is the founding member of a subfamily of zinc finger transcription factor genes.PLAG1, on human chromosome 8q12, encodes an essentially developmentally regulated protein and is causally implicated in human salivary gland pleomorphic adenomas, lipoblastomas, hepatoblastomas, and also AML, suggesting a more general importance for PLAG 1 in tumorigenesis.To study the oncogenic potential of PLAG 1 in mice, we developed PLAG 1 transgenic mouse strains, in which activation of overexpression of the transgene as well as the tissue distribution of such overexpression can be manipulated by Cre-mediated activation and targeted expression, respectively.Two independent PLAG 1 transgenic mouse strains, i.e.PTMS 1 and PTMS2, were generated.
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