【摘 要】
：
Growth factor (GF) signal transduction is now a generally accepted target for antitumor therapy.Various drugs targeting both ligand-binding and tyrosine kinase domains of GF receptors were developed a
【机 构】
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Receptor and Biomarker Study Group Laboratory of Clinical Biochemistry Russian N.N.Blokhin Cancer Re
【出 处】
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BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会)
论文部分内容阅读
Growth factor (GF) signal transduction is now a generally accepted target for antitumor therapy.Various drugs targeting both ligand-binding and tyrosine kinase domains of GF receptors were developed and are successfully used in the treatment of several cancer types.Nevertheless, even the most successful molecular-targeted agents, such as Herceptin(R), are effective only in a limited group of patients with corresponding receptor positive tumors, and a substantial part of them becomes resistant to the treatment in a relatively short time.Quite a convincing number of experimental studies have demonstrated that both primary and acquired resistance to these receptor-targeted drugs is imposed by a constitutive activation of downstream signaling cascades such as PI3K/Akt and NF-kappaB pathways..
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