SD大鼠急性脑梗死静脉溶栓后脑内VEGF的表达与出血性转化的关系

来源 :中华医学会第十六次全国神经病学学术会议 | 被引量 : 0次 | 上传用户：dengliguo1971

【摘要】

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【作者】

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李刚周广平李颖

【机构】

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同济大学附属东方医院神经内科新疆维吾尔自治区喀什地区莎车县人民医院脑系科

【出处】

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中华医学会第十六次全国神经病学学术会议

【发表日期】

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2013年7期

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目的:研究大鼠急性脑梗死静脉溶栓后脑内VEGF的表达与出血性转化的关系.方法:建立大鼠自体血栓脑梗死模型,选择栓塞后不同时间点(6h,9h,12h,24h,30h),采用Western Blotting方法测定缺血半暗带区VEGF表达,比较rtPA静脉溶栓组和对照组的差异,观察VEGF的表达与出血性转化的关系.结果:在各时间点,溶栓组VEGF表达的平均值均高于对照组,在24h时间点达到统计学差异;发生梗死后出血的模型中,VEGF的表达显著上升.结论:大鼠自体血栓脑梗死后静脉溶栓治疗有促进缺血侧脑组织VEGF表达的趋势,VEGF可能与出血性转化形成有关.

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SD大鼠急性脑梗死静脉溶栓后脑内VEGF的表达与出血性转化的关系

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