【摘 要】
：
The biological basis for the association between Epstein-Barr virus positive Hodgkin Lymphoma (EBV+HL) and HLAclass Ⅰ alleles is unclear.HLA-class Ⅰ presents viral peptides for recognition by CD8+ T-c
【机 构】
：
Queensland Institute of Medical Research Australia
【出 处】
：
BIT`s 1st Annual International Symposium of Hematology-2012(
论文部分内容阅读
The biological basis for the association between Epstein-Barr virus positive Hodgkin Lymphoma (EBV+HL) and HLAclass Ⅰ alleles is unclear.HLA-class Ⅰ presents viral peptides for recognition by CD8+ T-cells.Our aim was to further understand the immunological influence of HLA-A alleles on susceptibility to EBV+HL.In healthy subjects, antigen presentation for a range of relevant CD8+ T-cell EBV-latent epitopes was consistently higher in HLA-A2 than HLAA1 and/or A3 subjects.In HL patients, EBV+HL patients had diminished immunity against EBV-nuclear antigen-1 and Latent Membrane Proteins· 1 and 2A relative to EBVHL patients.We show that for a malignancy expressing a restricted set of poorly immunogenic viral proteins, even a modest CD8+ T-cell response against a relevant tumour associated antigen appears protective.Our data advances the understanding of genetic susceptibility to viral associated malignancies, and has implications for EBV vaccine design.
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