Synthesis and Purification of Cis-Tetrahydro Tarboline Ester

来源 :中国化学会全国第十二届有机合成化学学术研讨会 | 被引量 : 0次 | 上传用户：a15813225802

【摘要】

：

　　Cis-tetrahydro tarboline ester,i.e(1R,3R)-methyl-1,2,3,4-tetrahydro-1-(3,4-methyl ene-dioxyphenyl)-9H-pyrido [3,4-b]indole-3-carboxylate hydro-chloride is a

【作者】

：

WangCai-yi;SunJing-guo;

【机构】

：

College of chemistry and materials science,Hebei Normal University,Shijiazhuang,Hebei,050024

【出处】

：

中国化学会全国第十二届有机合成化学学术研讨会

【发表日期】

：

2015年期

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论文部分内容阅读

　　Cis-tetrahydro tarboline ester,i.e(1R,3R)-methyl-1,2,3,4-tetrahydro-1-(3,4-methyl ene-dioxyphenyl)-9H-pyrido [3,4-b]indole-3-carboxylate hydro-chloride is a key chiral intermediate of tadalafil[1].Tadalafil is a potent and selective inhibitor of the cyclic guanosime monophosphate(cGMP)-specific phosphor diesterase enzyme,PDE-5.

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Synthesis and Purification of Cis-Tetrahydro Tarboline Ester

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