We report here a case of recurrent paratyphoid fever A with hepatitis A co-infection in a patient with chronic hepatitis B.A 26-year-old male patient, who was a hepatitis B virus carrier, was co infected with Salmonella enterica serovar Paratyphi A and hepatitis A virus.The recurrence of the paratyphoid fever may be ascribed to the coexistence of hepatitis B, a course of ceftriaxone plus levofloxacin that was too short and the insensitivity of paratyphoid fever A to levofloxacin.We find that an adequate course and dose of ceftriaxone is a better strategy for treating paratyphoid fever.Furthermore, the co-infection of paratyphoid fever with hepatitis A may stimulate cellular immunity and break immunotolerance.Thus, the administration of the anti-viral agent entecavir may greatly improve the prognosis oth this patient with chronic hepatitis B,and the episodes of paratyphoid fever and hepatitis A infection prompt the use of timely antiviral therapy.