BMECG调控神经干细胞Notch信号通路的实验研究

来源 :中国药理学会网络药理学专业委员会成立大会暨首届网络药理学学术会议 | 被引量 : 0次 | 上传用户：zhxg01

【摘要】

：

目的:为了验证白脉散有效成分组(BMECG)对脑神经干细胞Notch信号通路相关因子的作用,及其对缺血脑组织中神经干细胞(NSCs)增殖的影响.方法:将健康雄性SD大鼠随机分为假手术组、MCAO模型组3h、6h、24h、72h、7d组、及给药治疗后3h、6h、24h、72h、7d组,每组12只.采用线栓法制作大鼠MCAO/R模型,神经行为学评分后,采用TTC及HE染色技术检测脑梗死体积及病理改变;

【作者】

：

陈小玉庄述娟李旭刘庆山

【机构】

：

中央民族大学中国少数民族传统医学研究院,北京100081;天津港口医院,天津,300456 中央民

【出处】

：

中国药理学会网络药理学专业委员会成立大会暨首届网络药理学学术会议

【发表日期】

：

2014年3期

【关键词】

：

网络药理学 BMECG 神经干细胞 Notch通路 Notch1 Hes1

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

Development and validation of a novel computational approach to identify epigenetic biomarkers assoc

Background: DNA methylation is one of the essential epigenetic mechanisms that are closely correlated to the prognosis progression in human cancer.Advances in computational approaches have generated m

会议

Cancer prognosisDNA methylationSurvival analysis

Stereoselective metabolism of phencynonate isomers and their molecular docking with the mAChR

Aim: To study the stereoselective metabolism of phencynonate isomers and their molecular docking with the mACh receptor.Methods: Phencynonate enantiomers were isocratically separated and determined by

会议

phencynonatechiral metabolismcytochrome P450protein bindingCaco-2 cellsmole

Regulation and new target of G protein-coupled receptors signalling networks in rheumatoid arthritis

Objective: G protein-coupled receptors (GPCRs) signalling networks are involved in many pathophysiological processes including pathways relevant in Rheumatoid arthritis(RA).GPCRs signaling, such as ad

会议

G protein-coupled receptorsrheumatoid arthritisdendritic cellsGRK2CP-25

Liquid chromatography-mass spectrometry based metabonomic investigation into the potential biomarker

Aim: To investigate the metabonomics and potential biomarkers for acute repetitive hypoxia.Methods: The metabonomics methods utilizing LC-MSn and multivariate statistical technique have been successfu

会议

metabonomicsbiomarkersacute repetitive hypoxiamice brainLC-MS

Chemopreventive efficacy of menthol on carcinogen-induced cutaneum carcinoma through inhibition of i

Inflammation and oxidative stress have been implicated in various pathological processes including skin tumorigenesis.Skin cancer is the most common form of cancer responsible for considerable morbidi

会议

Skin tumorigenesisCancer chemopreventionMentholInflammationOxidative stress

A fast analysis of fragmentation pathways of four representative pentacyclic triterpenoids by LC-ESI

Aim: The representative pentacyclic triterpenoids including madecassic, asiatic, ursolic and glycyrrhetinic acids, have been found to possess many pharmacological effects.This study is to conduct an a

会议

pentacyclic triterpenoidsfragmentation pathwaysmetabolitesLC-ESI-MSn

Mechanisms of Huangqi Decoction Against Rat Liver Fibrosis: a Gene Expression Profiling Analysis

Aim: To investigate the effects and mechanisms of HuangQi decoction (HQD) on the rat liver fibrosis by gene expression profiling and gene network analysis.Methods: Huangqi decoction (HQD) treated rat

会议

Huangqi decoctionliver fibrosisgene expression profilingnetworkdrug targets

Network-based virtual screening of active ingredients in Chinese herbal formulae for the treatment o

Objectives: This research aims to construct and analyze chemical ingredients network of herbal formulae, and provide potential active ingredients and ingredient groups for further pharmacological inve

会议

chemical ingredients networkherbal formulaecoronary heart diseasenetwork phar

Revealing the combination principles of herbal pair Euphorbia kansui and Glycyrrhiza used in the the

BACKGROUND: Although herbal pair Euphorbia kansui (GS)/Glycyrrhiza (GC) is one of the so-called "Eighteen antagonistic medicaments", it is prescribed in a classic Traditional Chinese Medicine (TCM) fo

会议

herb-herb combinationEuphorbia kansuiGlycyrrhizahepatocellular carcinoma asci

VEGF、CYP1A1基因多态性与肺癌易感性及相关影响因素的网络药理学研究

目的:采用网络药理学的方法研究肺癌易感性与VEGF、CYP1A1基因多态性及相关因素的关系,分析肺癌易感性-VEGF、CYP1A1基因多态性-影响因素之间的相互关系.方法:PubMed检索出VEGF基因、CYP1A1基因多态性与肺癌易感性相关的所有文献(检索范围为2014年1 1月21日前)使用基因搜索功能将基因名称校正为官方名称,并将物种设定为人类,并搜索与肺癌、VEGF、CYP1A1相关的所有

会议

网络药理学肺癌易感性VEGFCYP1A1基因多态性

BMECG调控神经干细胞Notch信号通路的实验研究

与本文相关的学术论文