Objective To analysis the intolerance to 14 kinds of food in the general population in Hefeito provide a scientific basis for disease prevention and further epidemiological investigation.Methods Selecting the people taking health examination at the first affiliatedhospitalofanhuimedical university from March 2011 to August 2013 as the research object,We used Enzyme-linked immunosorbent assay to determine serum concentration of 14 kinds food allergen-specific IgG antibody in the physical examination people.The test results were divided into four levels according to the instruction of test kits,level 0 (＜50 U/ml) for negative,level 1(50～100U/ml) for light sensitive,level 2 (100～200 U/ml) for moderate sensitive and level 3 (＞200 U/ml) for highly sensitive.All statistical analyses performed using the chi-square test,and P values＜0.05 were considered significant.