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Background The homeodomain-containing transcription factor HOXA9 is a core element of the HOXA9 enhanceosome and plays important roles in hematopoiesis and leukemogenesis.It can activate the expression of bcl2, c-myb, pim-1 and igflr.But whether this protein is regulated by post-translational modification is still unclear.In this study, we explored the sumoylation of HOXA9 and its regulation on transcriptional activity of HOXA9.