【摘 要】
:
Oncology drug discovery and development program has been a key research area in both academic institutions and biopharmaceutical industrial throughout the world.Anticancer drugs have originated from a
【机 构】
:
Pharmaron, Inc.China
论文部分内容阅读
Oncology drug discovery and development program has been a key research area in both academic institutions and biopharmaceutical industrial throughout the world.Anticancer drugs have originated from all available chemical sources including synthetic chemicals, natural products, antibodies, recombinant proteins, synthetic peptides, biological peptides, and gene therapeutics.There is no shortage of chemical sources; the challenge has been to find new molecular targets presented specifically in malignant cells and have the potential to be therapeutically important and confirmed by preclinical studies and clinical trials.
其他文献
Mitochondria are emerging as intriguing targets for anti-cancer agents.We tested here a novel approach, whereby the mitochondrially targeted delivery of anti-cancer drugs is enhanced by the addition o
As the best-characterized ubiquitin-like protein (UBL), small ubiquitin-related modifier (SUMO) was found to conjugate with a number of proteins to regulate cellular functions including transcription,
Cancer is a class of life-threatening diseases in which abnormal cells divide without control.It is now believed that angiogenesis is obligatory for the growth and progression of solid tumors.Tumor la
We designed and synthesized a new family of aminothiol radioprotectors; the lead molecule, PrC210, was highly radioprotective.Three design elements included: i) small size for efficient transmembrane
Chemotherapy is a common treatment for many cancers, especially for those metastatic cancers.Induced apoptosis is an important mechanism of chemotherapeutic agents to eliminate cancer cells.Apoptosis
Drug resistance is a major cause of failure in cancer chemotherapy.Therefore, identification and combined use of adjuvant compounds that can overcome drug resistance may improve the efficacy of cancer
The mitotic kinase Aurora-A (Aur-A) is required to form the bipolar spindle and ensure accurate chromosome segregation before cell division.Aur-A dysregulation represents an oncogenic event that promo
First line therapy in the treatment of gliomas and malignant melanomas are alkylating agents.These agents induce different DNA lesions, one of them is O6-methylguanine (O6MeG).This damage is a highly
Poly(ADP-ribose) polymerase-1 (PARP-1) plays important roles in multiple DNA damage response pathways rendering it a promising target in cancer therapy.However, cytoprotective effects of PARP1 inhibit
Therapeutic monoclonal antibody is the fastest growing class of drugs since the last decade.The advantages are its high specificity, low toxicity, long circulation half-life as well as the common prod