【摘 要】
：
Insulin-like growth factor 1 (IGF-1) is implicated in the nociceptive (pain)sensitivity of primary afferent neurons.We found that the IGF-1 receptor (IGF-1R)functionally stimulated voltage-gated T-typ
【机 构】
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Soochow University, China
【出 处】
：
The 6th Asian Pain Symposium, APS 2015(第六届亚洲疼痛研讨会)
论文部分内容阅读
Insulin-like growth factor 1 (IGF-1) is implicated in the nociceptive (pain)sensitivity of primary afferent neurons.We found that the IGF-1 receptor (IGF-1R)functionally stimulated voltage-gated T-type Ca2+ (CaV3) channels in mouse dorsal root ganglia (DRG) neurons through a mechanism dependent on heterotrimeric G protein (heterotrimeric guanine nucleotide-binding protein) signaling.
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