【摘 要】
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Background, Motivation and Objective Microbubble is a widely used ultrasound contrast agent, whose structure is a spherical shell encapsulating inertial gas. However, due to the micrometer size, micro
【机 构】
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Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kon
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Background, Motivation and Objective Microbubble is a widely used ultrasound contrast agent, whose structure is a spherical shell encapsulating inertial gas. However, due to the micrometer size, microbubbles are limited within blood circulation, so they are mainly used for mapping blood vessels. Recently, biogenetic nano gas vesicles at the size of ~250nm were reported [1], and they become possible to travel across the endothelial layer and reach targeted cells beyond. The objective of this study is to investigate the nonlinear acoustic property of these gas vesicles, and understand its potential in contrast enhanced ultrasound imaging. Specifically, we would like to identify its resonance frequency and examine the harmonic response by ultrasound stimulation.
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