The Rad9-Rad1-Hus1 (9-1-1) complex,evolutionarily conserved from yeast to human,plays crucial roles in DNA repair and cell cycle checkpoint control.The complex
Cells that carry unrepaired DNA damage are subject to arrested DNA replication,a lethal event unless the arrest is relieved and normal DNA replication continues
MCPH1/microcephalin is proposed to function in ATM- and ATR-mediated DNA damage response (DDR),and controls cell cycle progression and genomic stability.After i
Reversible protein phosphorylation by kinases and phosphatases is one of the most common mechanisms in controlling most,if not all cellular processes.The phosph
Maintaining genomic integrity through DNA repair is essential to the neuronal function.Cumulative evidence has implied that the central nervous system (CNS) is
Increasing lines of evidence have shown that non-protein coding RNAs,such as microRNAs,siRNAs and antisense RNAs,play important roles in the regulation of plant
Genetic alterations and cytopathological heterogeneity are hallmarks of cancer,in particular glioblastoma multiforme (GBM),contributing to the intractability of
Systemic lupus erythematosus (SLE) is a heterogeneous,multisystem autoimmune disease that is associated with organ failure in a significant proportion of patien
Chronic immune activation is a hallmark of progressive HIV infection and the major factor of disease progression.Bacterial lipopolysaccharide (LPS) in the circu
Saccadic eye movements are central to primate behavior and serve to move the eyes to visual objects of interest.Express saccades,unlike regular saccades,occur w